Fishing here means walking to the water first. Most of the trout streams inside the wilderness are miles from a road, and the reward for the walk is water almost nobody else has cast into that week.
Brown and rainbow trout hold in both major rivers, among the most productive trout water in Georgia, and virtually any tributary above about 1,500 feet carries wild trout of its own. Two creeks outside the wilderness boundary, Mill Creek and Holly Creek, get stocked and are easier to reach, a reasonable choice for a shorter trip or a first outing. Inside the wilderness itself, nothing is stocked. Catch and release is not required by law in there, but it is the standing etiquette, since every fish taken out is one the water has to grow back on its own.
Brook trout, the only trout actually native to this range, are gone from it now, extirpated by a combination of historic logging, warming water, and competition from the browns and rainbows stocked here over the last century.
Lower down, the fish list changes. The Conasauga and the Jacks River both hold Coosa bass at lower elevation, a native black bass species found almost nowhere outside this river system. Holly Creek carries sunfish in its lower reaches. None of it gets the attention the trout do, and most of it is easier to reach.
A Georgia fishing license and trout license are required. Check current regulations, including any closed sections, with the Georgia Department of Natural Resources before you fish.